Regent All Inclusive South America Cruises

A Symphony for the Senses

When you take an all-inclusive voyage to South America with Regent Cruise Destinations, you'll experience the vibrant life that carries across the continent - from Rio to Lima.

Tap into the passion and spirit of Buenos Aires as you dance the tango, and taste the history and culture of Peru as you learn to prepare pre-Columbian dishes in Lima. Enjoy a symphony for the senses in the flavors of Chilean bean stew and the dark fruit and spice aromas of Uruguayan red wines. Kayak across a tranquil lake in Patagonia and watch for playful pink dolphins and giant water lilies as you cruise the mighty Amazon River.

On an all-inclusive Regent cruise to South America, spacious suites and exquisite cuisine are a given as are dynamic and diverse cruise itineraries and free unlimited shore excursions.

Featured Offers & Promotions
 Free Extended Land Programs 
FREE Pre or Post-Cruise Land Programs featuring a Dune Dinner Safari in Abu Dhabi, Rome & the Vatican Museums, Wine Tasting in New Zealand and much more!
 Virtuoso Voyages 
EXCLUSIVE AMENITIES!
With Virtuoso Voyages, enjoy a private welcome reception and onboard host - plus your choice of a private shore event, personalized experience credit toward exclusive Vi...
CruisesShip Sort by ShipDate Sort by SaildateFare FromSavings
23-Nights from Cape Town to Lisbon Cruise New OfferingSeven Seas VoyagerJun 4, 2025$19,499
24-Nights from Cape Town to Lisbon CruiseSeven Seas MarinerApr 27, 2024$18,499
14-Nights from Cape Town to Rio de Janeiro Cruise  Seven Seas SplendorJan 5, 2025$14,949$7,448
10-Nights from Buenos Aires to Rio de Janeiro Cruise  Seven Seas SplendorMar 3, 2025$14,149$7,448
24-Nights Roundtrip from Miami Cruise Seven Seas MarinerNov 17, 2024$13,999$250
38-Nights from Cape Town to Santiago Cruise Seven Seas SplendorJan 5, 2025$32,899$6,798
24-Nights from Rio de Janeiro to Santiago Cruise Seven Seas SplendorJan 19, 2025$23,899$7,098
19-Nights from Santiago to Buenos Aires Cruise Seven Seas SplendorFeb 12, 2025$20,549$6,798
26-Nights from Buenos Aires to Lisbon Cruise Seven Seas SplendorMar 3, 2025$19,799$6,798
16-Nights from Rio de Janeiro to Lisbon Cruise Seven Seas SplendorMar 13, 2025$12,549$7,098
16-Nights from Miami to Los Angeles CruiseSeven Seas GrandeurDec 13, 2024$11,099
150-Nights from Miami to San Francisco CruiseSeven Seas MarinerJan 7, 2025$97,499
168-Nights Roundtrip from Miami CruiseSeven Seas MarinerJan 7, 2025$108,799
16-Nights from Los Angeles to Miami CruiseSeven Seas GrandeurJan 8, 2025$11,499
17-Nights from Miami to Rio de Janeiro CruiseSeven Seas MarinerJan 8, 2025$14,549
22-Nights from Rio de Janeiro to Santiago CruiseSeven Seas MarinerJan 25, 2025$22,449
18-Nights from Santiago to Papeete CruiseSeven Seas MarinerFeb 16, 2025$20,899
25-Nights Roundtrip from Miami CruiseSeven Seas NavigatorFeb 24, 2025$12,599
18-Nights from San Francisco to Miami CruiseSeven Seas MarinerJun 6, 2025$13,999
Fares are per person in US dollars, based on double occupancy. Savings, Onboard Credits and other amenity values are quoted per stateroom/suite. All prices, discounts and special offers are capacity controlled and subject to change without notice. Not all special offers available in all categories and sailings. Availability and pricing is not guaranteed until booking and deposit received.