Regent All Inclusive South America Cruises

A Symphony for the Senses

When you take an all-inclusive voyage to South America with Regent Cruise Destinations, you'll experience the vibrant life that carries across the continent - from Rio to Lima.

Tap into the passion and spirit of Buenos Aires as you dance the tango, and taste the history and culture of Peru as you learn to prepare pre-Columbian dishes in Lima. Enjoy a symphony for the senses in the flavors of Chilean bean stew and the dark fruit and spice aromas of Uruguayan red wines. Kayak across a tranquil lake in Patagonia and watch for playful pink dolphins and giant water lilies as you cruise the mighty Amazon River.

On an all-inclusive Regent cruise to South America, spacious suites and exquisite cuisine are a given as are dynamic and diverse cruise itineraries and free unlimited shore excursions.

Featured Offers & Promotions
 Upgrade Your Horizon - Free Suite Upgrade 
Enjoy a free 2-Category Suite Upgrade when you book a select cruise sailing through June 2025. With 50% reduced deposits and 20% savings on select 2023 cruises.
Offer ends 3/31/2023.
 Free Extended Land Programs 
FREE Pre or Post-Cruise Land Programs featuring a Dune Dinner Safari in Abu Dhabi, Shanghai & The Great Wall of China, Rome & the Vatican Museums, Wine Tasting in New Zealand and more!
 Virtuoso Voyages 
EXCLUSIVE AMENITIES!
With Virtuoso Voyages, enjoy a private welcome reception and onboard host - plus your choice of a private shore event, personalized experience credit toward exclusive Vi...
CruisesShip Sort by ShipDate Sort by SaildateFare FromSavings
154-Nights Roundtrip from Miami Cruise New OfferingSeven Seas MarinerJan 10, 2026$0
24-Nights Roundtrip from Miami Cruise Seven Seas NavigatorMar 28, 2023$13,999$13,000
21-Nights from Lima to Buenos Aires Cruise  Seven Seas SplendorDec 20, 2023$18,399$13,350
12-Nights from Buenos Aires to Rio de Janeiro Cruise  Seven Seas SplendorJan 10, 2024$12,699$13,350
24-Nights from Rio de Janeiro to Santiago Cruise  Seven Seas VoyagerJan 26, 2024$22,799$17,748
19-Nights from Santiago to Buenos Aires Cruise  Seven Seas VoyagerFeb 19, 2024$19,399$17,748
10-Nights from Buenos Aires to Rio de Janeiro Cruise  Seven Seas VoyagerMar 9, 2024$12,299$18,048
16-Nights from Miami to Lima Cruise Seven Seas SplendorDec 4, 2023$11,799$13,000
25-Nights Roundtrip from Miami Cruise Seven Seas MarinerDec 12, 2023$13,999$13,000
16-Nights from Miami to Los Angeles Cruise Seven Seas GrandeurDec 21, 2023$10,349$13,000
16-Nights from Los Angeles to Miami Cruise Seven Seas GrandeurJan 8, 2024$9,799$13,000
30-Nights from Buenos Aires to Miami Cruise Seven Seas SplendorJan 10, 2024$20,499$13,000
14-Nights from Cape Town to Rio de Janeiro Cruise Seven Seas VoyagerJan 12, 2024$13,449$17,698
18-Nights from Rio de Janeiro to Miami Cruise Seven Seas SplendorJan 22, 2024$13,099$13,300
28-Nights from Buenos Aires to Lisbon Cruise Seven Seas VoyagerMar 9, 2024$18,499$17,398
18-Nights from Rio de Janeiro to Lisbon Cruise Seven Seas VoyagerMar 19, 2024$11,899$13,300
24-Nights Roundtrip from Miami Cruise Seven Seas MarinerNov 17, 2024$12,849$13,000
16-Nights from Miami to Los Angeles Cruise Seven Seas GrandeurDec 13, 2024$10,399$13,000
14-Nights from Cape Town to Rio de Janeiro Cruise Seven Seas SplendorJan 5, 2025$14,699$13,300
38-Nights from Cape Town to Santiago Cruise Seven Seas SplendorJan 5, 2025$29,899$13,000
16-Nights from Los Angeles to Miami Cruise Seven Seas GrandeurJan 8, 2025$10,399$13,000
24-Nights from Rio de Janeiro to Santiago Cruise Seven Seas SplendorJan 19, 2025$23,499$13,300
19-Nights from Santiago to Buenos Aires Cruise Seven Seas SplendorFeb 12, 2025$19,699$13,000
25-Nights Roundtrip from Miami Cruise Seven Seas NavigatorFeb 24, 2025$11,799$13,000
10-Nights from Buenos Aires to Rio de Janeiro Cruise Seven Seas SplendorMar 3, 2025$13,299$13,300
26-Nights from Buenos Aires to Lisbon Cruise Seven Seas SplendorMar 3, 2025$18,399$13,000
16-Nights from Rio de Janeiro to Lisbon Cruise Seven Seas SplendorMar 13, 2025$11,799$13,300
67-Nights Roundtrip from Miami CruiseSeven Seas SplendorDec 4, 2023$42,399
132-Nights Roundtrip from Miami CruiseSeven Seas MarinerJan 6, 2024$98,299
17-Nights from Miami to San Francisco CruiseSeven Seas MarinerJan 7, 2024$15,499
150-Nights from Miami to San Francisco CruiseSeven Seas MarinerJan 7, 2025$94,499
168-Nights Roundtrip from Miami CruiseSeven Seas MarinerJan 7, 2025$105,799
17-Nights from Miami to Rio de Janeiro CruiseSeven Seas MarinerJan 8, 2025$14,799
22-Nights from Rio de Janeiro to Santiago CruiseSeven Seas MarinerJan 25, 2025$22,599
18-Nights from Santiago to Papeete CruiseSeven Seas MarinerFeb 16, 2025$19,599
18-Nights from San Francisco to Miami CruiseSeven Seas MarinerJun 6, 2025$14,149
Fares are per person in US dollars, based on double occupancy. Savings, Onboard Credits and other amenity values are quoted per stateroom/suite. All prices, discounts and special offers are capacity controlled and subject to change without notice. Not all special offers available in all categories and sailings. Availability and pricing is not guaranteed until booking and deposit received.